Polymerase trafficking
نویسندگان
چکیده
منابع مشابه
Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking
Most cystic fibrosis is caused by mutations in CFTR that prevent its trafficking from the ER to the plasma membrane and is associated with exaggerated inflammation, altered metabolism, and diminished responses to oxidative stress. PARP-1 is activated by oxidative stress and causes energy depletion and cell dysfunction. Inhibition of this enzyme protects against excessive inflammation and recent...
متن کاملLa Protein and the Trafficking of Nascent RNA Polymerase III Transcripts
Several small nuclear and cytoplasmic RNAs are synthesized by RNA polymerase (Pol) 1 III as nascent transcripts that must then migrate through RNA processing, modification, and transport machinery on their trek to becoming mature, functional molecules. The first factor to interact with newly synthesized Pol III transcripts is the La protein. Evidence that this molecular chaperone accompanies pr...
متن کاملhuman trafficking in central asia
human trafficking is one form of organized crime with 7 to 10 billion dollars profit next to drug and weapon trades. former soviet republics and eastern europe have become the newest sources of human trafficking, for europe and north america for the purpose of sexual exploitation .this article is a result in causes of human trafficking in central asian republic of the former soviet :union:.
متن کاملLatonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.
Cystic fibrosis (CF) is a major lethal genetic disease caused by mutations in the CF transmembrane conductance regulator gene (CFTR). This encodes a chloride ion channel on the apical surface of epithelial cells. The most common mutation in CFTR (F508del-CFTR) generates a protein that is misfolded and retained in the endoplasmic reticulum. Identifying small molecules that correct this CFTR traf...
متن کاملIntracellular trafficking.
Studies in C. elegans have begun to reveal new components and new mechanisms associated with intracellular membrane traffic in a variety of cell types. The worm benefits from many of the advantages of yeast as a genetically tractable organism for these kinds of studies while offering the unique opportunity to probe how these pathways have been extended and modified in the context of a multicell...
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ژورنال
عنوان ژورنال: Transcription
سال: 2010
ISSN: 2154-1264,2154-1272
DOI: 10.4161/trns.1.3.13488